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David Grainger

BMedSc (Hons)


DPhil Student

Modelling developmental haematopoiesis in vitro

During my undergraduate degree in Medical Science at the University of Birmingham, I gained a competitively funded position in Dr Laura O’Neill’s laboratory investigating the effect of histone demethylase inhibition on X-inactivation in female mouse embryonic stem cells. Subsequently, in my final year at Birmingham, I joined the lab of Professor John Frampton under the supervision of Dr Giacomo Volpe to investigate the role of the transcriptional repressor, GFI1, in cytogenetically-normal AML. I moved to the University of Oxford in October 2017 to join Professor Catherine Porcher’s laboratory in the Weatherall Institute of Molecular Medicine to study for my DPhil in Medical Science. My DPhil project aims to unpick the reasons underlying the incomplete development of haematopoietic stem cells from current in vitro differentiation cultures of embryonic stem cells and more closely recapitulate the timing, strength and combination of signals that occur during embryonic development

Publications

Volpe, G., D. S. Walton, D. E. Grainger, C. Ward, P. Cauchy, D. Blakemore, D. J. L. Coleman, P. N. Cockerill, P. Garcia and J. Frampton (2017). "Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature." Scientific Reports 7(1): 11148