BSc, MSc, PhD
Senior Postdoctoral researcher
My research interests are focused in: 1) defining new mechanisms by which innate immune receptors control antigen presentation and adaptive immune responses; 2) characterising tissue inflammation in inflammatory bowel disease (IBD) using single cell technology.
Innate immune system through pattern recognition receptors (PRRs) detect and translate signals of evolutionarily conserved pathogen-associated molecular patterns (PAMPs) into rapid host defenses, triggering sequential activation of intracellular signaling pathways that lead to induction of a range of cytokines and prime the adaptive immune response for long lasting-protection. The physiological importance of PRRs in maintaining a finely balanced immune response becomes apparent when signals derived from these components are dysregulated due to functional or genetic defects. An example of such dysregulation comes from the polymorphisms within the NOD2 gene, which represents the most frequent genetic defect in Crohn’s disease (CD). By using large-scale screening techniques, such as phospho-proteomic analysis, I am exploring how the activation of innate immune sensors, including NOD2, forms molecular signaling platforms in primary human cells required for antigen degradation and cross-presentation to lymphocytes.
To define new drug targets in IBD, I am characterising human resident lymphocytes in intestinal mucosa (Trm) using single-cell RNAseq, which allows in-depth molecular characterisation of rare or difficult to access human cells. A deep characterisation of different subsets of resident lymphocytes in intestinal mucosa is used to address in vivo studies to validate the effect of distinct immune subsets in immunity and to aid development of therapies devoted to modifying the resident T cells’ behavior and, perhaps, long-term residence and location in the intestine.
I joined the Simmons Lab at the University of Oxford in April 2015. Previously, I started my Ph.D. in Immunology at the University of L’Aquila (Italy) studying innate immune processes related to the pathogenesis of chronic inflammatory diseases. During the second year of my Ph.D., I was selected to continue my research project at Case Western Reserve University in the Digestive Health Research Center (Cleveland, USA) under the supervision of Professor Fabio Cominelli. I obtained my Ph.D. degree in April 2012. I then started a post-doctoral fellowship at Case Western Reserve University (2012-2015) working on a project investigating the role of NOD2 signaling pathway in the pathogenesis of IBD employing in vivo experimental models of chronic intestinal inflammation.
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.
Chapman TP. et al, (2019), Front Immunol, 10
NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.
Corridoni D. et al, (2019), Front Immunol, 10
Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease.
Corridoni D. et al, (2018), Front Med (Lausanne), 5
Innate immune receptors for cross-presentation: The expanding role of NLRs.
Corridoni D. and Simmons A., (2017), Mol Immunol
Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Corridoni D. et al, (2017), Mucosal Immunol, 10, 971 - 982