B.Pharm, M.Pharm, PhD
Postdoctoral Research Scientist
My current research work at Prof TH Rabbitts Lab is focused on formulation and development of various targeted nanoparticulate systems for the intracellular delivery of drugs and drug surrogates (antibody fragments/ nucleic acids) leading to intervention of protein-protein interactions at subcellular level especially cancer associated oncogenic protein interactions.
Previously, I studied BPharm from Devi Ahliya University and MPharm in Pharmaeutical Biotechnology from Dr HS Gour University, India. During my Master’s resarch project I synthesized various diblock and triblock (BAB and ABA) coploymers of PLA and PEG for their potential application as a mucosal vaccine delivery system. In 2008, I joined ISF college of Pharmacy, Moga where I taught undergraduate and post graduate modules, and co-supervised a Master’s research project. Right before leaving India for my doctoral studies I was working as an associate at Indian Institute of Technology Kanpur, where I developed and characterised electrosparyed polysccharide microparticles for colon targeting application.
During my PhD in 2010 at School of Pharmacy, Queen’s University Belfast with Dr VL Kett, I developed a novel nanoparticle-in-nanoparticle system for the prolonged and effective gene delivery to the posterior eye as a prophylactic measure to Retinopathy of Prematurity. A range of physicochemical and thermodynamic studies were performed to regulate the condensation of pDNA with a cationic cell penetrating peptide, RALA, to achieve the nanoparticles of defined size distribution. These nanoparticles were then encapsualted within the biodegradable PLA-PEG nanoparticles to guide their path to the posterior eye.
Development of polymeric-cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery.
Jain AK. et al, (2015), Int J Nanomedicine, 10, 7183 - 7196
Electrosprayed inulin microparticles for microbiota triggered targeting of colon.
Jain AK. et al, (2014), Carbohydr Polym, 112, 225 - 234
Development of a method to quantify the DNA content in cationic peptide-DNA nanoparticles.
Jain AK. et al, (2014), J Pharm Biomed Anal, 100, 236 - 242
Evaluation of mucoadhesive carrier adjuvant: toward an oral anthrax vaccine.
Mangal S. et al, (2014), Artif Cells Nanomed Biotechnol, 42, 47 - 57
Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally.
Mangal S. et al, (2011), Vaccine, 29, 4953 - 4962