Anna-Lena completed her BA in Natural Sciences at the University of Cambridge, where she developed an interest in immune regulation and its breakdown in chronic inflammatory and autoimmune diseases. She then moved to the University of Oxford to pursue an MSc in Integrated Immunology followed by a D.Phil. with Dr Holm Uhlig and Prof Fiona Powrie. In her thesis she investigated the role of human innate lymphoid cells in intestinal inflammation. Anna-Lena joined the Fugger lab as a Postdoctoral Researcher in April 2016 and will be applying her previous experience in cellular immunology to the investigation of immune dysregulation in multiple sclerosis, with an emphasis also on the potential translational implications of her research.
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
Pearson C. et al, (2016), Elife, 5
Human ILC-T-cell interactions in inflammatory bowel disease
Schaupp A-L. et al, (2014), IMMUNOLOGY, 143, 103 - 103
IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion.
Gutowska-Owsiak D. et al, (2012), Exp Dermatol, 21, 104 - 110
Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes.
Gutowska-Owsiak D. et al, (2011), Br J Dermatol, 165, 492 - 498