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David Clynes, a postdoc in the MRC Molecular Haematology Unit, has been awarded a Children with Cancer UK Research Fellowship.
Translational Dermatology Unit
MRC TIDU
The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
RAMADAN GROUP
DNA Damage Response
D'ANGIOLELLA GROUP
Cell Cycle and Ubiquitin Signalling
Dong Group | T cell responses against Viruses & Cancer
MRC TIDU
Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.
Kusumbe Lab | Tissue and Tumor Microenvironments
MRC TIDU
We Study Vascular Changes Over Time With The Aim To Treat Diseases
Koohy Group: Machine Learning and Integrative Approaches in Immunology
Centre for Computational Biology MRC TIDU
We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.
Wilkinson Group: Blood Stem Cell Expansion and Fitness
MRC MHU
Haematopoietic stem cells (HSCs) support blood cell production throughout life and are also used clinically in cell and gene therapies. We are studying the biology of this important stem cell population with the aim of developing new HSC-based therapies.
Sahakyan Group: Integrative Computational Biology and Machine Learning
Centre for Computational Biology
Combining computational biology, computational chemistry, and machine learning techniques with biological big data to unravel the higher genomic code of life.
de Bruijn Group: Developmental Haematopoiesis
MRC MHU
We study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.
Psaila Group: The tumour microenvironment in blood cancers
MRC MHU
We focus on four key areas: (1) Dissecting how blood cancers create 'self-reinforcing' niches that promote clonal expansion and protect malignant clones from immunotherapies; (2) Development and application of human bone marrow organoids to study normal and malignant haematopoiesis and validate targets in a relevant tissue microenvironment; (3) Developing novel strategies to selectively target cancer stem cells and pathological megakaryocytes in myelofibrosis, a severe bone marrow malignancy; (4) Understanding our recent discovery that platelets contain a repertoire of DNA fragments sequestered from cell free DNA, and confirming clinical utility for cancer detection and for pre-natal diagnosis.