Images of MRC WIMM research — MRC Weatherall Institute of Molecular Medicine

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Pseudo-colouring the overlapping domains of expression of three marker genes for paraxial, intermediate and lateral plate mesoderm in a transverse section of an eight-day old mouse embryo creates a rainbow effect. Each spot in the rainbow is a single mRNA molecule stained by hybridisation chain reaction.

© David Grainger

David Grainger

$Super-resolution STED microscopy, performed at a custom-made system, versus confocal microscopy image. Human fibroblast cells transfected with the peroxisomal matrix marker GFP-SCP2 (blue) fixed and immunolabelled for peroxisomal receptor PEX5 (red) and mitochondria marker Tom20 (green). STED microscopy reveals details beyond the diffraction barrier, paving the way to new biological insights.$ © Silvia Galiani

Silvia Galiani

This is an image of the failed, but unexpectedly beautiful, experiment. A young zebrafish embryo (70% epiboly stage) was unspecifically stained for three different fluorescently labelled transcripts using the hybridisation chain reaction technique. I like this image because it resembles an image of a planet.

© Martyna Lukoseviviute

Martyna Lukoseviviute

Megakaryocytes (green) are imaged on a monolayer of endothelial cells (magenta) with which they interact to generate platelets.

© Abdullah Khan

Abdullah Khan

Generating artificial vasculature is an area of significant interest in the tissue engineering field. The production of branching networks supported by pericytes in a 3D mixed matrix hydrogel is imaged here.

© Abdullah Khan

Abdullah Khan

$Super-resolution STED microscopy versus confocal microscopy of proteins at peroxisomes. Image of fibroblast cells transfected with the peroxisomal matrix marker GFP-SCP2 (blue) fixed and immunolabelled for PEX14 (red) and PEX5 (green). STED microscopy reveals details beyond the diffraction barrier, paving the way to new biological insights.$ © Silvia Galiani

Silvia Galiani

WIMM is the scientific wonderland, gives me a fantastic scientific journey.

© Luyao Wang

Luyao Wang

A lateral view of a 14 somite stage zebrafish embryo, head to tail. Immunofluorescence staining was performed to visualise neural crest cells expressing different transcription factors.

© Martyna Lukoseviviute

Martyna Lukoseviviute

Induced pluripotent stem cells (iPSC) can be used to generate primitive ‘organoids’ which reproduce physiological structures, and allow us to more accurately study disease pathologies. Here, iPSCs are differentiated to mak a vascularised organoid which we use to study the effects of Covid19 on the microvasculature.

© Abdullah Khan

Abdullah Khan

The image displays an optical section of an ovariole (a serial unit of an ovary, female reproductive organ) of a honeybee queen pupae. Ovarioles were stained with phalloidin (in cyan) for filamentous cellular actin visualisation, cell membrane dye (in magenta) and cell nuclei (with DAPI in yellow).

© Martyna Lukoseviviute

Martyna Lukoseviviute

A monolayer of primary human dermal lymphatic endothelial cells captured by confocal microscope. Cells were immunostained with antibodies again the junctional adhesion molecule CD31 (green) and transcription factor Prox-1 (red).

© Louise Johnson

Louise Johnson

A ventral view of a 14 somite stage zebrafish embryo, head to tail. Hybridisation chain reaction was used to simultaneously stain transcripts of two soxtranscription factors involved in central nervous system development and a wnt gene coding for a signalling protein important for embryo patterning.

© Martyna Lukoseviviute

Martyna Lukoseviviute

WIMM is the scientific wonderland, gives me a fantastic scientific journey.

© Luyao Wang

Luyao Wang

Dissolving as little as 1 gram of the Coomassie Brilliant Blue Dye in 10% acetic acid and 40% methanol.

© Martin Fellermeyer

Martin Fellermeyer

© Salwa Lin

Salwa Lin

Whole mount immunofluorescence confocal microscopy of mouse dermis, with lymphatic vessels stained with anti-LYVE-1 (blue) and blood vessels stained with anti-perlecan (red)

© Louise Johnson

Louise Johnson

A dorsal view of an optical section of a zebrafish tailbud. Hybridisation chain reaction method was used to simultaneously stain transcripts (in magenta and yellow) of transcription factors controlling neuromesodermal progenitor fates. Nuclei were stained with DAPI (in cyan).

© Martyna Lukoseviviute

Martyna Lukoseviviute

Megakaryocytes are the rarest and largest cells of the bone marrow, responsible for the generation of blood platelets by making unique, long beaded extensions called pro platelets. Here we use Megakaryocytes derived from induced pluripotent stem cells to look at the effects of genetic mutations on pro platelet formation.

© Abdullah Khan

Abdullah Khan

Super-resolution Airyscan confocal imaging of a human dendritic cell, with CD44 (green) and the glycosaminoglycan hyaluronan (red) at the cell surface, detected by antibody and biotinylated hyaluronan binding probe VG-1 respectively, and nucleus counterstained with DAPI.

© Louise Johnson

Louise Johnson

Shown is the inside of the Biacore 8K during a run to analyse the affinity of nanobodies.

© Martin Fellermeyer

Martin Fellermeyer

Over-segmentation of the posterior of an eight-day old mouse embryo using a watershed algorithm. Each region has been assigned a random colour creating a stained-glass effect.

© David Grainger

David Grainger

The image shows a section of the human bone marrow from a myelofibrotic patient, analysed by imaging mass cytometry using the Hyperion Cytof recently acquired by the WIMM.

© Michela Colombo

Michela Colombo

WIMM is the scientific wonderland, gives me a fantastic scientific journey.

© Luyao Wang

Luyao Wang

Abdullah Khan

A dorsal view of a zebrafish tailbud. Hybridisation chain reaction method was used to simultaneously stain transcripts of transcription factors controlling neuromesodermal progenitor and neural crest fates.

© Martyna Lukoseviviute

Martyna Lukoseviviute

A view of an early zebrafish embryo dorsal tailbud. Hybridisation chain reaction method was used to simultaneously visualise multiple transcripts driving neuromesodermal progenitor fates. These progenitors will contribute to the zebrafish spinal cord and muscles.

© Martyna Lukoseviviute

Martyna Lukoseviviute

Whole mount immunofluorescence confocal microscopy of a lymphatic vessel within mouse dermis, with junctions between individual endothelial cells stained with for LYVE-1 (blue) and VE-cadherin (red), and a VE-cadherinhi LYVE-1- blood capillary in the background.

© Louise Johnson

Louise Johnson

A view of an early zebrafish embryo, dorsal tailbud is located on the left. Hybridisation chain reaction method was used to simultaneously visualise multiple transcripts driving neuromesodermal progenitor fates. These progenitors will contribute to the zebrafish spinal cord and muscles.

© Martyna Lukoseviviute

Martyna Lukoseviviute

Depicted are real-time binding curves of nanobodies analysed by SPR using the Biacore 8K. Parts of the machine are seen on the right.

© Martin Fellermeyer

Martin Fellermeyer

Langerhans cells (LC) are tissue-resident DCs found in the epidermal layer of the skin. CD1a is an MHC class - I like protein abundantly expressed on LCs. LCs have crucial roles in immune surveillance and homeostasis, however, lipid antigens presented by CD1a has been shown to amplify inflammatory responses in skin inflammation. The image shows CD1a staining on LCs in healthy skin – the dendrites protruding in the epidermal layer sensing for antigens

© Randeep Singh

Randeep Singh

Co-culture of tumour cells (red cells) on top of a layer of endothelial cells (image acquired using bright-field microscopy at WIMM)

© Salwa Lin

Salwa Lin

Abdullah Khan

Whole mount immunofluorescence confocal microscopy of a junction between endothelial cells of a lymphatic vessel within mouse dermis. Individual lymphatic endothelial cells overlap, with LYVE-1+ flaps (blue) anchored by VE-cadherin (red), “buttoning” the cells together.

© Louise Johnson

Louise Johnson

The image shows over 130k cells of human HSPCs from both healthy individuals and myelofibrosis patients. Each dot is a single cell and the colour refers to different lineages. Large expanded purple ‘tails’ are the cancer cells in myelofibrosis patients.

© Guanlin Wang

Guanlin Wang