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Cross-presentation is important for regulating T-cell responses to exogenous antigens and can maintain tolerance (cross-tolerance) or induce immune responses (cross-priming). Recent exciting results on the role of the Toll-like receptor TLR3 in promoting cross-priming of viral antigens provide new insights into the mechanisms that allow Toll-like receptor signaling to bridge innate and adaptive immune responses.

Original publication

DOI

10.1016/j.cub.2005.04.025

Type

Journal article

Journal

Curr Biol

Publication Date

10/05/2005

Volume

15

Pages

R336 - R339

Keywords

Antigen Presentation, Antigens, Viral, Cross-Priming, Dendritic Cells, Humans, Immunity, Cellular, Membrane Glycoproteins, RNA, Double-Stranded, Receptors, Cell Surface, Signal Transduction, T-Lymphocytes, Toll-Like Receptor 3, Toll-Like Receptors