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Recent population genetic studies of the distribution of alpha+-thalassaemia in Melanesia using DNA analysis have provided strong support for the hypothesis that high frequencies of this genetic disorder are the result of natural selection by malaria.

Original publication

DOI

10.1159/000205870

Type

Journal article

Journal

Acta Haematol

Publication Date

1987

Volume

78

Pages

173 - 179

Keywords

Age Factors, Animals, Brain Diseases, Erythrocytes, Genotype, Globins, Humans, Malaria, Melanesia, Models, Genetic, Plasmodium, Selection, Genetic, Thalassemia