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A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.

Original publication

DOI

10.1016/j.carres.2012.02.034

Type

Journal article

Journal

Carbohydr Res

Publication Date

15/07/2012

Volume

356

Pages

152 - 162

Keywords

Animals, Antigens, CD1d, Carbohydrate Conformation, Catalysis, Cells, Cultured, Click Chemistry, Dimerization, Galactosylceramides, Injections, Intravenous, Interferon-gamma, Ligands, Mice, Mice, Inbred C57BL, Models, Molecular, Natural Killer T-Cells, Protein Binding, Small Molecule Libraries, Spleen