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A detailed sequence comparison of the MSX homeobox family sheds light on its evolution and identifies new conserved motifs. But in the absence of corroborative genetic data, phylogenomics alone can provide only limited insights into the pathogenicity of heterozygous missense substitutions in human genes.

Original publication

DOI

10.1186/jbiol127

Type

Journal article

Journal

J Biol

Publication Date

2009

Volume

8

Keywords

Amino Acid Sequence, Base Sequence, Conserved Sequence, Genetic Predisposition to Disease, Genomics, Homeodomain Proteins, Humans, MSX1 Transcription Factor, Mouth Abnormalities, Mutation