New technology helps decode the genetic changes behind disease
Researchers from the Milne, Hughes and Davies Groups have developed a new technology that can reveal new therapeutic targets from common genetic variants linked to disease.
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Translating Our Research
Leading research with the aim of improving human health. World-leading research from scientists at the MRC WIMM has been developed into commercial ventures to translate our discoveries into clinics and benefit patients.
Read moreImmune sensor can detect viral infection by monitoring cell’s own RNA
A recent study by the Rehwinkel Group and collaborators reveals a new way the immune sensor MDA5 can recognise viral infection – not only through viral RNA, but by monitoring changes to the cell’s own RNA processing.
Read moreEveryday DNA damage reveals a hidden weakness in some cancers
Researchers in the Chapman Group have discovered why cancer cells lacking a protein called ATM are particularly vulnerable to a class of cancer drugs known as PARP inhibitors, solving a scientific puzzle that has challenged researchers for nearly 20 years.
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Discover. Translate. Advance.
The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.
Read moreMRC Translational Immune Discovery Unit
Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.
MRC Molecular Haematology Unit
Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.
Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat a range of human diseases.
Latest publications
Can It Happen Again? Using Co-Produced Theatre to Explore the Challenges Faced by Couples Considering Pregnancy After a De Novo Genetic Diagnosis in a Child.
Journal article
Kay A. et al, (2026), Health Expect, 29
Type I interferon-activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis.
Journal article
Nathwani V. et al, (2026), Cell Rep, 45
Zone Equalisation Normalisation for Improved Alignment of Epigenetic Signal.
Journal article
Wilson T. et al, (2026), Bioinformatics
Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.
Journal article
Sampaio NG. et al, (2026), Nat Immunol
Upcoming Seminars
OSE / RDM Entrepreneurial Talk - The Story Behind Next-Generation DNA Sequencing
Wednesday, 14 October 2026, 12pm to 1pm
Speaker(s): Professor Sir David Klenerman FRS (Yusuf Hamied Department of Chemistry, Cambridge University) https://www.ch.cam.ac.uk/person/dk10012
Series: OSE / RDM Entrepreneurial Talk
WIMM Seminar - Malignant Transformation of the Immune System and Precision Therapy for Immune Neoplasms
Thursday, 15 October 2026, 12pm to 1pm
Speaker(s): Dr Ari Melnick (Josep Carreras Leukaemia Research Institute Barcelona) https://www.carrerasresearch.org/en/directory/ari-matthew-melnick-1010
Series: WIMM THURSDAY SEMINARS
Mucosal Immune Responses to Respiratory Infections
Friday, 16 October 2026, 9.15am to 10.15am
Speaker(s):
Prof Elena Mitsi
(Oxford Vaccine Group, University of Oxford)
https://www.ovg.ox.ac.uk/team/eleni-mitsi
Dr Nile Verleur
(Oxford Vaccine Group, University of Oxford)
Series: FRI AM lab meetings
Evolving in vitro and in vivo drug testing towards clinically relevant preclinical models of KMT2A-rearranged infant ALL – Lessons learned (the hard way)
Tuesday, 20 October 2026, 1pm to 2pm
Speaker(s): Ronald Stam (Prinses Maxima Centrum) https://www.prinsesmaximacentrum.nl/en/professionals/researchers/ronald-stam
Series: Molecular Haematology Unit