Prof Zameel Cader MRCP
|Research Area:||Integrative Physiology (Systems Biology)|
|Technology Exchange:||Biobanking, Bioinformatics, Drug discovery, ES cell / homologous recombination, Ex vivo models, Human genetics, In vivo imaging, Magnetic resonance imaging & spectroscopy, Microscopy (Confocal), Mouse models, Protein interaction, Transcript profiling and Transgenesis|
|Scientific Themes:||Molecular, Cell & Systems Biology and Translational Medicine & Medical Technology|
|Keywords:||induced pluripotent stem cells, migraine, drug discovery, neuroscience, single cell and transcriptomics|
Our aim is to elucidate the pathophysiological basis of human neurological disorders from genetic molecular networks to complex neural systems. We achieve this through development of relevant disease models that will then serve as novel and robust platforms for drug discovery.
Our cellular models range from primary cell cultures to human induced pluripotent stem cell lines derived directly from patients. This allows us to identify the molecular and cellular signatures of neurogenetic disorders using omics analysis, cellular imaging and electrophysiology. We also aim to construct more relevant neuronal models through tissue engineering and 3D cell culture.
Ensuring molecular and cellular phenotypes are relevant to disease requires in vivo models. We therefore employ model organism such as the fly to validate hypotheses and findings from our in vitro systems. We are also undertaking human imaging studies, in collaboration with FMRIB.
|Prof Kevin Talbot||NDCN||United Kingdom|
|Dr Holly Bridge||FMRIB||United Kingdom|
|Dr Jason J Davies||Chemistry||Oxford University,|
|Prof Chris Ponting||MRC Functional Genomics Unit||University of Oxford||United Kingdom|
|Prof Jes Olesen||Danish Headache Center||Denmark|
|Prof Irene Tracey||FMRIB Centre, Unversity of Oxford||United Kingdom|
There are no publications listed for this principal investigator.