Prof Zameel Cader MRCP

Research Area: Integrative Physiology (Systems Biology)
Technology Exchange: Biobanking, Bioinformatics, Drug discovery, ES cell / homologous recombination, Ex vivo models, Human genetics, In vivo imaging, Magnetic resonance imaging & spectroscopy, Microscopy (Confocal), Mouse models, Protein interaction, Transcript profiling and Transgenesis
Scientific Themes: Molecular, Cell & Systems Biology and Translational Medicine & Medical Technology
Keywords: induced pluripotent stem cells, migraine, drug discovery, neuroscience, single cell and transcriptomics
Web Links:
Differentiating Cortical Neurons from Induced Pluripotent Stem Cells

Differentiating Cortical Neurons from Induced Pluripotent Stem Cells

Brain Networks in Migraine

Brain Networks in Migraine

Our aim is to elucidate the pathophysiological basis of human neurological disorders from genetic molecular networks to complex neural systems. We achieve this through development of relevant disease models that will then serve as novel and robust platforms for drug discovery.

Our cellular models range from primary cell cultures to human induced pluripotent stem cell lines derived directly from patients. This allows us to identify the molecular and cellular signatures of neurogenetic disorders using omics analysis, cellular imaging and electrophysiology. We also aim to construct more relevant neuronal models through tissue engineering and 3D cell culture.

Ensuring molecular and cellular phenotypes are relevant to disease requires in vivo models. We therefore employ model organism such as the fly to validate hypotheses and findings from our in vitro systems. We are also undertaking human imaging studies, in collaboration with FMRIB.

Name Department Institution Country
Prof Kevin Talbot NDCN United Kingdom
Dr Holly Bridge FMRIB United Kingdom
Dr Jason J Davies Chemistry Oxford University,
Prof Chris Ponting MRC Functional Genomics Unit University of Oxford United Kingdom
Prof Jes Olesen Danish Headache Center Denmark
Prof Irene Tracey FMRIB Centre, Unversity of Oxford United Kingdom

There are no publications listed for this principal investigator.