Selected publications

• Tanaka Tomoyuki and Rabbitts Terence H (2010) Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture. Nat Protoc, 5(1):67-92.

• Rabbitts Terence H (2009) Commonality but diversity in cancer gene fusions. Cell, 137(3):391-5.

• Forster Alan, Pannell Richard, Drynan Lesley F, Codrington Rosalind, Daser Angelika, Metzler Markus, Lobato M N, and Rabbitts Terence H (2005) The invertor knock-in conditional chromosomal translocation mimic. Nat Methods, 2(1):27-30.

• McCormack Matthew P, Young Lauren F, Vasudevan Sumitha, de Graaf Carolyn A, Codrington Rosalind, Rabbitts Terence H, Jane Stephen M, and Curtis David J (2010) The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science, 327(5967):879-83.

• Daser Angelika, Thangavelu Madan, Pannell Richard, Forster Alan, Sparrow Louise, Chung Grace, Dear Paul H, and Rabbitts Terence H (2006) Interrogation of genomes by molecular copy-number counting (MCC). Nat Methods, 3(6):447-53.

Prof Terry Rabbitts

We wish to define how chromosomal translocation genes affect proliferation and differentiation from cancer initiating cells (where translocations occur) to overt cancer, and in epithelial cancers, to invasive disease. This work amalgamates technologies for creating in vivo models of chromosomal translocations that mark the cancer initiating cells by fluorescent protein expression with transcriptomic analysis (concentrating on the surfaceome and transcription factor expression patterns).

The second, allied arm of our work, involves establishing technologies to target protein-protein interactions using antibody fragments as drug surrogates for functional ablation of target proteins. We are isolating small molecules that mirror the inhibitory properties of the antibody fragments & the goals are to develop laboratory reagents to study cancer development and drug-like molecules for therapeutic use.