WIMM Publications
S Bowman, D Lawson, D Basham, D Brown, T Chillingworth, C M Churcher, A Craig, R M Davies, K Devlin, T Feltwell, S Gentles, R Gwilliam, N Hamlin, D Harris, S Holroyd, T Hornsby, P Horrocks, K Jagels, B Jassal, S Kyes, J McLean, S Moule, K Mungall, L Murphy, K Oliver, M A Quail, M A Rajandream, S Rutter, J Skelton, R Squares, S Squares, J E Sulston, S Whitehead, J R Woodward, C Newbold, and B G Barrell (1999)
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
Nature, 400(6744):532-8.
Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.
