WIMM Prize Studentships 2018

colonies banner_short

4 Year WIMM Prize PhD Studentships - H817033 and
Oxford Sir David Weatherall Scholarship

The MRC Weatherall Institute of Molecular Medicine (WIMM) has fully funded 4-year Prize PhD (DPhil) studentships available to start in October 2018.  These studentships are open to outstanding students of any nationality who wish to pursue a career in experimental and/or computational biology.

Along with applications for the WIMM Prize Studentships, we also invite applications for the Oxford-Sir David Weatherall Scholarship, which is associated with Green Templeton College.  This fully funded 4-year scholarship is open to outstanding candidates of all nationalities.

Interviews will take place the week commencing 22 January 2018.  All shortlisted applicants will be invited to visit the Institute one day that week.  This will be for the whole day and will comprise a 30 minute interview (which will include a 5 minute presentation on your research to date), a tour of the WIMM and meeting potential supervisors.  Overseas candidate interviews will be conducted via Skype.

Participating supervisors and projects are listed below.  Applicants are encouraged to contact prospective supervisors to express their interest and discuss possible projects.

How to apply:

All applications must be made using the University's online application form

Please read the  University of Oxford Graduate application guide

Deadline for applications is 12 Noon (UK time) on  Monday, 8 January 2018

Specific details required in the application form:

IMPORTANT
1.  RDM Scholars Programme - if also applying for the RDM Scholars Programme please also put “RDM SCHOLARS 18”Do not make a separate application for each scholarship /studentship.
 
2.   Oxford - Sir David Weatherall Scholarship - This studentship comes with a college place at Green Templeton College http://www.gtc.ox.ac.uk, Oxford's youngest graduate college.  Green Templeton’s fellows and students are drawn from the medical sciences, management and social sciences with academic interests in issues relating to human welfare. If you wish to be considered for the Oxford - Sir David Weatherall Scholarship in parallel with your WIMM application, you need to submit an additional statement of not more than 500 words, on why Green Templeton College would be attractive to you and how you would contribute to College life. 

Further Information:

Eligibility

Information on eligibility can be found at the DPhil in Medical Science information page.

Further information/enquiries.

Please contact Mrs Liz Cloke, WIMM Student Co-ordinator, liz.cloke@imm.ox.ac.uk or Tel:  +44 (0) 1865 222336.

Participating supervisors and projects

Project

No

Supervisor

Project Title

WIMM CENTRE FOR COMPUTATIONAL BIOLOGY PROJECTS

W27

Hashem Koohy and  Alain Townsend

Mechanisms underlying off-target V(D)J recombination

W32

Claus Nerlov and Ed Morrissey

Quantitative modelling of the role of hematopoietic stem- and progenitor niches in cell fate decisions.

W40

Aleksandr Sahakyan and Doug Higgs

Analysing the evolution of regulatory chromosomal domains: fundamental units of the genome?

W44

Supat Thongjuea and Claus Nerlov

High-resolution promoterome mining for insights transcriptional regulation of the lineage-biased hematopoietic stem cells

W45

Supat Thongjuea and Claus Nerlov

Computational analysis toolkit for exploring sparse and large-scale single-cell data

WIMM PROJECTS

W01

Ahmed Ahmed

Role of stem cells in tumour initiation

W02

Christian Babbs, Irene Roberts and Richard Gibbons

Pathogenesis of congenital dyserythropoietic anaemia Type I

W03

Oliver Bannard and Alain Townsend

Antibody affinity maturation in germinal centres during influenza A infection

W04

Andrew Blackford

Understanding the regulation of DNA double-strand break repair pathway choice

W05

Sir Walter Bodmer

Differentiation and drug response evaluation in colorectal cancer

W06

Marella de Bruijn

Analysis of blood stem cell lineage specification in mammalian development

W07

Zam Cader

Molecular signatures and computational biology of patient stem cell derived dementia models

W08

David Clynes, Richard Gibbons and Peter McHugh

Targeting telomeric transcription as a potential cancer therapy

W09

Simon Davis and Vincenzo Cerundolo

New combinations of immune-checkpoint inhibitors to treat cancer

W10

Tao Dong and Yanchun Peng

Characterisation of Viral OncoProtein (VOP) and Tumor specific Protein (TSP) specific T cell responses in HPV virus associated Cervical and head-neck Cancers

W11

Tao Dong and Dannielle Wellington

The impact of IFITM3 genetic variation on virus infection, immune responses and disease outcome

W12

Alexander Drakesmith

Iron and the immune response

W13

Christian Eggeling and Vincenzo Cerundolo

Microscopy-based studies of CD1d and MR1 assisted T-cell activation

W14

Christian Eggeling and Simon Davis

Microscopy-based analysis of lipid and lipid-anchored protein organization at the T-cell surface

W15

Marco Fritzsche and Vincenzo Cerundolo

Dissecting the ability of PD-1 signalling-events in altering actin cytoskeleton dynamics in tumour infiltrating T lymphocytes.

W16

Marco Fritzsche and Tao Dong

Dissecting early calcium signalling-events in controlling effector function of T lymphocytes

W17

Marco Fritzsche and Christian Eggeling

Actin cytoskeleton-mediated force generation during T-cell activation investigated by advanced (super-resolution) microscopy

W18

Lars Fugger

Functional genetics in multiple sclerosis: determining the translational potential

W19

Tudor Fulga

Design and implementation of CRISPR/Cas9-based prosthetic gene networks for research and therapeutic application

W20

Richard Gibbons and Doug Higgs

Chromatin remodelling and gene expression

W21

Anne Goriely and Andrew Wilkie

Analysis of de novo mutations in the human testis

W22

Anne Goriely and Andrew Wilkie

Impact of de novo mutations and mosaicism in human disease: applications to non-invasive diagnostic techniques

W23

Doug Higgs and Danuta Jeziorska

Investigating the role of enhancers in the recruitment of RNA polymerase II to the α-globin promoter in live cells in real time

W24

Ling-Pei Ho

Influenza virus infection, monocytes, macrophages and their roles in lung fibrosis

W25

Georg Holländer

The molecular and cellular basis of thymus development and central T cell tolerance induction

W26

David Jackson

Mechanisms  underlying  the trafficking  of leucocytes from tissues via the lymphatics in immunity and inflammation

W28

Peter McHugh

Understanding how replication-coupled DNA repair protects against ageing and cancer

W29

Adam Mead

Single cell analysis of malignant stem cell clones in myelofibrosis

W30

Adam Mead and Claus Nerlov

In vivo modelling of mutation order and oncogene addiction in myeloproliferative neoplasms

W31

Claus Nerlov

The role of the microenvironment in hematopoietic ageing

W33

Claus Nerlov and Sten Eirik Jacobsen

The role of hematopoietic stem cell heterogeneity in hematopoietic emergency responses

W34

Claus Nerlov and Paresh Vyas

In vivo modelling of order and hierarchical position of oncogenic mutation in acute myeloid leukemia (AML)

W35

Graham Ogg

Role of lipid-specific T cells in human inflammation and translational development of new therapies to treat allergic disease

W36

Graham Ogg

Role of innate lymphoid cells in skin inflammation

W37

Catherine Porcher

Studying blood stem cell development through single cell and lineage tracing analyses

W38

Jan Rehwinkel

Investigating innate immune signalling with CRISPR-Cas9 screens

W39

Jan Rehwinkel

Defence and counter-defence: The interplay between Zika virus and the immune system

W41

Tatjana Sauka-Spengler

Specifying neural crest cell from ‘scratch’

W42

Alison Simmons

The function of pattern recognition receptors in immune homeostasis and inflammation

W43

Alison Simmons

Mechanisms of intestinal barrier function in health and inflammation

W46

Paresh Vyas and Claus Nerlov

Characterisation of molecular pathways of differentiation in normal human lympho-myeloid differentiation using a systems biology approach

W47

Paresh VyasClaus Nerlov and Andrew Smith

Niche determinants required for leukaemic and normal stem cell function

W48

Paresh Vyas and Irene Roberts

Human model of DS-AML: Identifying mechanisms of differentiation arrest leading to Acute Myeloid Leukaemia

W49

Alain Townsend and Pramila Rijal

Human monoclonal antibodies to monitor antigenic drift in influenza virus

W50

Andrew Wilkie and  Steve Twigg

Exome and whole genome sequencing to identify new genetic causes of skull malformations

W51

Andrew Wilkie  and  Steve Twigg

How do cranial sutures work?

W52

Ben Fairfax

Deep characterization of trans acting context specific expression quantitative trait loci

W53

Tom Milne

A single cell analysis of MLL-AF4 leukaemias