Occasional WIMM Seminars

Thu 2 Mar 2017 from 13:00 to 14:00

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Proteomic modeling of erythropoiesis

Dr Marjorie Brand

Audience: Members of the University only

Organisers: Liz Rose

Tue 14 Mar 2017 from 11:00 to 12:00

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Visualising and understanding the control of chromatin organisation

Dr Abder Kaidi

Re-establishment of nuclear structure and chromatin organisation after cell division is integral for genome regulation and cell function. However, the mechanisms underlying this process remain incompletely understood. To address this, we developed imaging approaches to visualise chromatin... Read more

Re-establishment of nuclear structure and chromatin organisation after cell division is integral for genome regulation and cell function. However, the mechanisms underlying this process remain incompletely understood. To address this, we developed imaging approaches to visualise chromatin organisation in intact cells. These include: florescence lifetime imaging microscopy (FLIM), florescence correlation spectroscopy (FCS), and electron microscopy. Thus, we identify a new role for nuclear actin in organising chromatin after mitosis. Interference with this function influences transcription and replication in the daughter cells. These findings identify a novel spatiotemporally controlled form of nuclear actin that contributes to the chromatin organization after cell division. This has implications for understanding the mechanisms underlying the overall organisation of the mammalian somatic cell nucleus.

Audience: Members of the University only

Organisers: Penny Berry

Wed 22 Mar 2017 from 13:00 to 14:00

MRC Weatherall Institute of Molecular Medicine, Conference Room, Headington OX3 9DS

LMO2 protein complexes driving haematopoietic cell fate and leukaemogenesis

Dr Trang Hoang

Audience: Members of the University only

Organisers: Liz Rose

Thu 23 Mar 2017 from 11:15 to 12:15

MRC Weatherall Institute of Molecular Medicine, Conference Room, Headington OX3 9DS

"A common functional role of SCL and LYL1 in red cell and platelet production”

Prof David Curtis

Audience: Members of the University only

Organisers: Liz Rose