Occasional WIMM Seminars

Wed 15 Jun 2016 from 15:15 to 16:15

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

A systems biology approach to identifying drug targets and predicting therapeutic outcomes in myelodysplasia and acute myeloid leukaemia

Ass. Professor John Pimanda

Dr Pimanda will present results from a body of work using functional genomics to develop tools to predict drug response in Myelodysplasia (MDS), identify alternate treatment options for patients who fail current treatment and characterise treatment related changes to the sub-clonal architecture and... Read more

Dr Pimanda will present results from a body of work using functional genomics to develop tools to predict drug response in Myelodysplasia (MDS), identify alternate treatment options for patients who fail current treatment and characterise treatment related changes to the sub-clonal architecture and function of dysplastic haematopoietic stem/progenitor cells (HSPCs). He will also present an integrative analysis of long intergenic non-coding RNA (lincRNAs) expression from 922 acute myeloid leukemia patients. These analyses show that leukemic and normal hematopoietic cell subsets express distinct lincRNAs and that gene signatures composed of as few as three lincRNA genes are independent predictors of clinical outcome across multiple patient cohorts.

Audience: Members of the University only

Organisers: Liz Rose

Wed 29 Jun 2016 from 13:30 to 14:30

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Development of the AGM region in the chick embryo

Dr Tom Schultheiss

Audience: Members of the University only

Organisers: Liz Rose