Occasional WIMM Seminars

Tue 5 Apr 2016 from 13:00 to 14:00

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

DNA repair, NAD+ and mitophagy in neurodegeneration and ageing

Dr Evandro Fang

Ageing is emerging as a universal problem bringing formidable socioeconomic challenges. Studies on the mechanisms of ageing will facilitate our understanding of the process and will generate potential preventive strategies. Since no single ageing theory can satisfactorily explain all aspects of the... Read more

Ageing is emerging as a universal problem bringing formidable socioeconomic challenges. Studies on the mechanisms of ageing will facilitate our understanding of the process and will generate potential preventive strategies. Since no single ageing theory can satisfactorily explain all aspects of the ageing process, an integration of multiple theories on ageing is favored. The speaker will describe his latest studies on how two classical ageing hypotheses, persistent DNA damage and mitochondrial dysfunction, converge to explain premature ageing symptoms and contribute to neurological phenotypes in a series of ageing laboratory models. Emerging evidence suggests a critical role for DNA damage signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. The interconnected roles of DNA damage, NAD+, and mitophagy will be explored in relation to ageing and neurodegenerative diseases, especially Alzheimer’s disease.

Audience: Members of the University only

Organisers: Penny Berry

Wed 13 Apr 2016 from 16:00 to 16:45

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Evolutionary tradeoffs and the geometry of gene expression space

Professor Uri Alon

Uri Alon is a Systems Biologists at the Weizmann Institute of Science. He was trained as a physicist, but got hooked by the challenge of understanding the design principles of cells. His lab studies “biological networks and circuits, and more recently, also principles of human interactions, using... Read more

Uri Alon is a Systems Biologists at the Weizmann Institute of Science. He was trained as a physicist, but got hooked by the challenge of understanding the design principles of cells. His lab studies “biological networks and circuits, and more recently, also principles of human interactions, using a combined experimental and theoretical approach, aiming to uncover general underlying principles that govern their functioning and evolution” https://www.weizmann.ac.il/mcb/UriAlon/homepage. He did pioneering work in discovering network motifs, and was awarded, among others, the Overton Prize by the International Society for Computation Biology (2004) and the HFSP Nakasone Award (2014). He is a member of EMBO. Apart from his scientific credentials, Uri Alon is well known for his songs, TED talk and publications on the culture of science. Taking a leaf out of the book of improvisation theatre, he has been an inspiration to many on nurturing and supporting the next generation of scientists.

Audience: Members of the University only

Organisers: Linda Roberts

Wed 13 Apr 2016 from 17:15 to 18:00

Love and fear in the lab - a guitar talk on the importance of emotions in science

Professor Uri Alon

Audience: Members of the University only

Organisers: Liz Rose

Mon 25 Apr 2016 from 14:30 to 15:30

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Restriction of HIV-1 and HIV-2 infection in myeloid and lymphoid cells

Lise Chauveau

Audience: Members of the University only

Organisers: Anne Farmer

Fri 29 Apr 2016 from 11:30 to 12:30

DNA interstrand cross-link and mismatch repair

Dr Jean Gautier

Audience: Members of the University only

Organisers: Penny Berry

Fri 29 Apr 2016 from 13:00 to 14:00

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Noncoding RNA regulation of myeloid transcription factors, DNA methylation and leukaemia

Daniel G Tenen

Audience: Members of the University only

Organisers: Liz Rose