Key publications

Town, J., Pais, H., Harrison, S., Stead, L.F., Bataille, C., Bunjobpol, W., Zhang, J., Rabbitts, T.H. (2016) Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target. Proc. Natl. Acad. Sci. USA 113, 3603-3608
http://www.ncbi.nlm.nih.gov/pubmed/26979953

 

Chambers, J., Rabbitts, T.H. (2015) LMO2 at 25 years: a paradigm of chromosomal translocation proteins. Open Biol 5
http://www.ncbi.nlm.nih.gov/pubmed/26108219

 

Zhang, J. & Rabbitts, T.H.  (2014)  Intracellular Antibody Capture:  a molecular biology approach to inhibitors of protein-protein interactions.  BBA – Proteins and Proteomics 1844, 1970-1976 http://www.sciencedirect.com/science/article/pii/S1570963914001472

 

Chambers, J.S., Tanaka, T., Brend, T., Ali, H., Geisler, N.J., Khazin. L., Cigudosa, J.C., Dear, T.N., MacLennan, K. & Rabbitts, T.H. (2014) Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities. Cancer Res 74, 1588-1597 http://cancerres.aacrjournals.org/content/74/5/1588.long 

 

Sewell, H., Tanaka, T., El Omari, K., Mancini, E.J., Cruz, A., Fuentes-Fernandez, N., Chambers, J. & Rabbitts T.H. (2014) Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcriptional complex. Scientific Reports 4, 1-9  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887373/

 

Zeng, J., Zhang, J., Tanaka, T. & Rabbitts, T.H. (2013) Single Domain Antibody Fragments as Drug Surrogates Targeting Protein-Protein Interactions inside Cells Antibodies 2, 306-320

 

Tanaka, T. & Rabbitts, T.H. (2010) Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth; Oncogene 29, 6064-6070 
http://www.ncbi.nlm.nih.gov/pubmed/20818422

 

Pérez-Martinez, D., Tanaka, T., and Rabbitts, T.H. (2010) Intracellular antibodies and cancer: New technologies offer therapeutic opportunities. Bioessays 32, 589-598
http://www.ncbi.nlm.nih.gov/pubmed/20544739

 

McCormack, M. P., Young, L. F., Vasudevan, S, de Graff, C. A., Codrington, R, Rabbitts T. H., Jane, S. M., Curtis, D. J. (2010) The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science 327, 879-883  
http://www.ncbi.nlm.nih.gov/pubmed/20093438

 

Tanaka, T., Rabbitts, T.H. (2010) Protocol for the selection of single-domain fragments by third generation intracellular antibody capture  Nature Protocols 5, 67-92  http://www.ncbi.nlm.nih.gov/pubmed/20057382

 

Rabbitts, T.H. (2009) Commonality but diversity in cancer gene fusions  Cell 137, 391-394  http://www.ncbi.nlm.nih.gov/pubmed/19410533

 

Tanaka, T., Williams, R., & Rabbitts T.H. (2007) Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS EMBO J. 26, 3250-3259  http://www.ncbi.nlm.nih.gov/pubmed/17568777

 

Daser, A., Thangavelu, M., Pannell, R., Forster, A., Sparrow, L., Chung, G., Dear, P.H. & Rabbitts T.H. (2006) Interrogation of genomes by Molecular Copy-number Counting (MCC) Nature Methods  3, 447-453 
http://www.ncbi.nlm.nih.gov/pubmed/16721378

 

Forster, A., Pannell, R., Drynan, L.F., Codrington, R., Daser, A., Metzler, M., Lobato, M.N. & Rabbitts T.H. (2005) The invertor knock-in conditional translocation mimic Nature Methods 2,  27-30  http://www.ncbi.nlm.nih.gov/pubmed/15782166

 

Tse,E., Smith, A.J.H., Hunt, S., Lavenir, I., Forster, A., Warren, A.J., Grutz, G., Foroni, L., Carlton, M.B.L., Colledge, W.H., Boehm, T. &  Rabbitts, T.H. (2004)  Null mutation of the Lmo4 gene or combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice Mol Cell Biol.  24, 2063-2073  http://www.ncbi.nlm.nih.gov/pubmed/14966285

 

Tanaka, T, Lobato, M.N. & Rabbitts, T.H. (2003)  Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.   J. Mol. Biol.  331, 1109-1120  http://www.ncbi.nlm.nih.gov/pubmed/12927545

 

Forster, A., Pannell, R., Drynan, L. F., McCormack, M.M., Collins, E.C., Daser, A. & Rabbitts, T.H. (2003)  Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.  Cancer Cell   3,  449-458  http://www.ncbi.nlm.nih.gov/pubmed/12781363

 

Tse, E., Lobato, M., Forster, A., Tanaka, T., Chung, T.Y. & Rabbitts T.H. (2002)  Intracellular Antibody Capture Technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein  J. Mol Biol.   317, 85-94  http://www.ncbi.nlm.nih.gov/pubmed/11916380

 

Wadman, I.A., Osada, H., Grutz, G.G., Agulnick, A.D., Westphal, H., Forster, A. & Rabbitts, T.H. (1997) The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins  EMBO J. 16, 3145-3157  http://www.ncbi.nlm.nih.gov/pubmed/9214632

 

Corral, J., Lavenir, I., Impey, H., Warren, A.J., Forster, A., Bell, S., McKenzie, A.N.J., King, G. & Rabbitts, T.H. (1996) An Mll-AF9 fusion gene generated by homologous recombination causes acute leukaemia in chimeric mice: A general method to create fusion oncogenes.  Cell  85, 853-861  http://www.ncbi.nlm.nih.gov/pubmed/8681380

 

Rabbitts, T.H. (1994) Chromosomal translocations in human cancer.  Nature  372, 143-149.  http://www.ncbi.nlm.nih.gov/pubmed/7969446

 

Warren, A.J., Colledge, W.H., Carlton, M.B.L., Evans, M.J., Smith, A.J.H. & Rabbitts, T.H. (1994)  The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development.  Cell  78, 45-58. 
http://www.ncbi.nlm.nih.gov/pubmed/8033210

 

Cook, G.P., Tomlinson, I.M., Walter, G., Carter, N.P., Riethman, H., Buluwela, L., Winter, G. & Rabbitts, T.H. (1994)  A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.  Nature Genetics  7, 162-168.  http://www.ncbi.nlm.nih.gov/pubmed/7920635

 

Rabbitts, T.H., Forster, A., Larson, R. and Nathan, P.  (1993)  Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.  Nature Genetics 4, 175-180. 
http://www.ncbi.nlm.nih.gov/pubmed/7503811

 

Rabbitts, T.H.  (1991)  Translocations, master genes and differences between the origin of acute and chronic leukaemias.  Cell  67, 641-644. 
http://www.ncbi.nlm.nih.gov/pubmed/1934065

 

Kennedy, M., Boehm, T., Kees, U., Gonzalez-Sarmiento, R. and Rabbitts, T.H.  (1991)   HOX11, a homeobox T cell oncogene on human chromosome 10q24.  Proc. Natl. Acad. Sci. USA, 88, 8900-8904. 
http://www.ncbi.nlm.nih.gov/pubmed/1681546

 

Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.F. and Rabbitts, T.H.  (1991)  The rhombotin family of cysteine-rich LIM-domain oncogenes:  Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.  Proc. Natl. Acad. Sci. USA 88, 4367-4371.  http://www.ncbi.nlm.nih.gov/pubmed/2034676

 

Greenberg, J.M., Boehm, T., Sofroniew, M.V., Keynes, R.J., Barton, S.C., Norris, M.L., Surani, M.A., Spillantini, M.-G. and Rabbitts, T.H.  (1990)  Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system.  Nature  344, 158-160.  http://www.ncbi.nlm.nih.gov/pubmed/2106626

 

L. Buluwela, A. Forster, T. Boehm and T.H. Rabbitts  (1989)  A rapid procedure for colony screening using nylon filters.  Nucleic Acids Res.  17, 452. 
http://www.ncbi.nlm.nih.gov/pubmed/2911481

 

M.-P. Lefranc, A. Forster, R. Baer, M.A. Stinson and T.H. Rabbitts  (1986)  Diversity and rearrangement of the human T cell rearranging  genes:  Nine germ-line variable genes belonging to two subgroups.  Cell  45, 237-246. 
http://www.ncbi.nlm.nih.gov/pubmed/2938743

 

R. Baer, K.-C. Chen, S.D. Smith and T.H. Rabbitts  (1985)  Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumours.  Cell  43, 705-713. 
http://www.ncbi.nlm.nih.gov/pubmed/3935328

 

T.H. Rabbitts, M.-P. Lefranc, M.A. Stinson, J.E. Sims, J. Schroder, M. Steinmetz, N.L. Spurr, E. Solomon and P.N. Goodfellow  (1985)  The chromosomal location of T cell receptor genes and a T cell rearranging gene:  Possible correlation with specific translocations in human T cell leukaemias.  EMBO J.  4, 1461-1465. 
http://www.ncbi.nlm.nih.gov/pubmed/3875483

 

M.S. Neuberger, G.T. Williams, E.B. Mitchell, S.S. Jouhal, J.G. Flanagan and T.H. Rabbitts  (1985)  A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature  314, 268-270. 
http://www.ncbi.nlm.nih.gov/pubmed/2580239

 

T.H. Rabbitts, A. Forster, P.Hamlyn and R. Baer  (1984)  Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.  Nature  309, 592-597.  http://www.ncbi.nlm.nih.gov/pubmed/6547209

 

J.G. Flanagan, M.-P. Lefranc and T.H. Rabbitts  (1984)  Mechanisms of divergence and convergence of the human immunoglobulin 1 and 2 constant region gene sequences.  Cell  36, 681-688.  http://www.ncbi.nlm.nih.gov/pubmed/6421489

 

M. Davis, S. Malcolm and T.H. Rabbitts  (1984)  Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells.  Nature  308, 286-288.  http://www.ncbi.nlm.nih.gov/pubmed/6700731

 

T.H. Rabbitts, P.H. Hamlyn and R. Baer  (1983)  Altered nucleotide sequences of a translocated c-myc  gene in Burkitt lymphoma.  Nature  306, 760-765.  http://www.ncbi.nlm.nih.gov/pubmed/6419122

 

P.H. Hamlyn and T.H. Rabbitts  (1983)  Translocation joins c-myc  and immunoglobulin 1 genes in a Burkitt lymphoma, revealing a third exon in the c-myc  oncogene.  Nature  304, 135-139.  http://www.ncbi.nlm.nih.gov/pubmed/6306472

 

M.-P. Lefranc, G. Lefranc and T.H. Rabbitts  (1982)  Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals.  Nature  300, 760-762.  http://www.ncbi.nlm.nih.gov/pubmed/6817143

 

J.G. Flanagan and T.H. Rabbitts  (1982)  Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing ,  and  genes.  Nature  300, 709-713. 
http://www.ncbi.nlm.nih.gov/pubmed/6817141

 

S. Malcolm, P. Barton, C. Murphy, M.A. Ferguson-Smith, D.L. Bentley and T.H. Rabbitts  (1982)  Localisation of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridisation.  Proc. Natl. Acad. Sci. USA  79, 4957-4961.  http://www.ncbi.nlm.nih.gov/pubmed/6812058

 

D.L. Bentley and T.H. Rabbitts  (1981)  Human VKimmunoglobulin gene number:  Implications for the origin of antibody diversity.  Cell  24, 613-623. 
http://www.ncbi.nlm.nih.gov/pubmed/6265099

 

D.L. Bentley and T.H. Rabbitts  (1980)  Human immunoglobulin variable region genes - DNA sequences of two V genes and a pseudogene.  Nature  288, 730-733.  http://www.ncbi.nlm.nih.gov/pubmed/6779204

 

T.H. Rabbitts, A. Forster, W. Dunnick and D.L. Bentley  (1980)  The role of gene deletion in the immunoglobulin heavy chain switch.  Nature  283, 351-356.  http://www.ncbi.nlm.nih.gov/pubmed/6766206

 

T.H. Rabbitts  (1978)  Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA.  Nature  275, 291-296.  http://www.ncbi.nlm.nih.gov/pubmed/99668

 

T.H. Rabbitts and A. Forster  (1978)  Evidence for non-contiguous variable and constant region genes in both germline and myeloma DNA.  Cell   13, 319-327.  http://www.ncbi.nlm.nih.gov/pubmed/414842

 

T.H. Rabbitts  (1976)  Bacterial cloning of plasmids carrying copies of globin messenger RNA.  Nature  260, 221-225. 
http://www.ncbi.nlm.nih.gov/pubmed/768776

 

T.H. Rabbitts, J.M. Jarvis and C. Milstein  (1975)  Demonstration that a mouse immunoglobulin light chain messenger RNA hybridises exclusively with unique DNA.  Cell   6, 5-12.   http://www.ncbi.nlm.nih.gov/pubmed/809142