Your HLA Typing Results

There are hundreds of alleles in each of the HLA-A/B/C and HLA-DRB1 loci. The extreme polymorphism of these genes makes it very difficult to design a comprehensive set of SSP mixes that can be used routinely and efficiently. That is why we sometimes have to design subtyping reactions. However, the current set of 192 primers (now called Africa-10) can distinguish between several alleles or groups of alleles. When you get your HLA results, do not be alarmed by the nomenclature, it's explained below.

 

HLA Locus
MHC Class
Example Result
What it means
A
I
A*30(01/08)
One of 2 A30 alleles: either A*3001 or A*3008.
B
I
B*08(01/08N/11)
One of 3 B8 alleles: B*0801, B*0808N or B*0811.
Bw
 
Bw6
Each B allele is associated with either Bw4 or Bw6.
Cw
I
Cw*07(01/06)
One of 2 Cw7 alleles: Cw*0701 or Cw*0706.
DRB1
II
DRB1*04
There is insufficient data to assign an allele but the group of alleles is DRB1*04.
DRB3/4/5
II
DRB4
The combination of DRB3/4/5 genes determines haplotype: eg. if you have DRB1*04, you also are DRB4. If you are DRB1*15,you have DRB5.
DQB1
II

DQB1*03(01/04/09/10)
DQB1*03(02/07/08)
DQB1*03(03/12)

One of 4 DQB1*03 alleles.
One of 3 DQB1*03.
One of 2 DQB1*03.

 

NomenclatureIndicates
HLA the HLA region and prefix for an HLA gene
HLA-DRB1 a particular HLA locus i.e. DRB1
HLA-DRB1*13 a group of alleles which encode the DR13 antigen
HLA-DRB1*1301 a specific HLA allele
HLA-DRB1*1301N a null allele, DNA detectable but truncated/ no protein
HLA-DRB1*130101 an allele which differs by a synonymous mutation
(DNA sequence changed, protein remains the same)
HLA-DRB1*13010102 an allele which contains a mutation outside the coding region e.g. an intron
HLA-DRB1*13010102N a null allele which contains a mutation outside the coding region

 

Information here is taken from the IMGT/HLA Database