Consolidated List of all WIMM Seminars

Fri 7 Jul 2017 from 15:00 to 16:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Using NKT Cell Antigens as Vaccine Adjuvants

Professor Ian Hermans

Audience: Members of the University only

Organisers: Anne Farmer

Tue 11 Jul 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

MHU Student Presentations

Christopher Booth; Alba Rodriguez Meira, Caroline Harrold

Audience: Members of the University only

Organisers: Liz Rose

Wed 12 Jul 2017 from 10:30 to 11:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

A new approach for single cell whole genome amplification

Audience: Members of the University only

Organisers: Sarah Butler

Fri 14 Jul 2017 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Characterizing the molecular identity of dormant hematopoietic stem cells

Dr Florian Buettner

Audience: Members of the University only

Organisers: Sarah Butler

Wed 26 Jul 2017 from 15:30 to 16:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR

Dr Joseph Kwong

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumour-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts enhance colony formation of metastatic ovarian... Read more

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumour-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts enhance colony formation of metastatic ovarian cancer cells, and de novo expression of transforming growth factor-alpha (TGF-α) is induced in stromal fibroblasts co-cultured with ovarian cancer cells. We also observed an over-expression of tumour necrosis factor-alpha (TNF-α) in ovarian cancer cells, which is regulated by promoter DNA hypomethylation as well as chromatin remodelling. Interestingly, this ovarian cancer-derived TNF-α induces TGF-α transcription in stromal fibroblasts through nuclear factor-kB (NF-kB). We further show that TGF-α secreted by stromal fibroblasts in turn promotes peritoneal metastasis of ovarian cancer through epidermal growth factor receptor (EGFR) signalling. Finally, we identify a TNFα-TGFα-EGFR interacting loop between tumour and stromal compartments of human omental metastases. Our results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFα-TGFα-EGFR.

Audience: Members of the University only

Organisers: Penny Berry