Consolidated List of all WIMM Seminars

Thu 12 Jan 2017 from 11:00 to 11:45

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium

Christina Rode

Audience: Members of the University only

Organisers: Liz Rose

VIVA SEMINAR

Mon 16 Jan 2017 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Transcriptional programmes of leukaemic fusion genes: from “omcis” to drugs

Olaf Heidenreich

Audience: Members of the University only

Organisers: Linda Roberts

Tue 17 Jan 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

AML genetics, forward and reverse

Dr George Vassiliou

Audience: Members of the University only

Organisers: Liz Rose

Wed 18 Jan 2017 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

From happiness on twitter to the genome: Network based integrative approaches in epigenomics

Dr Vera Pancaldi

Audience: Members of the University only

Organisers: Anne Farmer

Fri 20 Jan 2017 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

A reexamination of Fc receptor triggering

Dr James Felce, Dr Erdinc Sezgin

Audience: Members of the University only

Organisers: Anne Farmer

Wed 25 Jan 2017 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Genetic and epigenetic determinants of blood cells and links to human disease

Professor Nicole Soranzo

Audience: Members of the University only

Organisers: Liz Rose

Thu 26 Jan 2017 from 11:30 to 12:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

The genetic and epigenetic principles of V(D)J recombination during B cell development

Dr Hashem Koohy

Audience: Members of the University only

Organisers: Anne Farmer

Thu 26 Jan 2017 from 14:00 to 15:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

The role of homologous recombination proteins in vertebrate DNA replication

Dr Vincenzo Costanzo

Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Lesions and discontinuities in the DNA template undergoing replication induce replication fork stalling. Homologous recombination (HR) proteins RAD51 and BRCA1/2 play a major... Read more

Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Lesions and discontinuities in the DNA template undergoing replication induce replication fork stalling. Homologous recombination (HR) proteins RAD51 and BRCA1/2 play a major role in the stability of replication forks. This function appears to be distinct from the classical one performed by these proteins in HR dependent DNA Double Strand Break repair. Using Xenopus laevis egg extract we discovered that RAD51 prevents MRE11 mediated degradation of nascent DNA at stalled forks in eukaryotic cells. This finding has been widely confirmed in different model systems. The use of electron microscopy mediated analysis of replication intermediates is allowing the dissection of several mechanistic aspects of HR proteins function in replication fork protection. I will address the crosstalk between BRCA1/2, RAD51 and the MRE11 complex in light of our more recent findings.

Audience: Members of the University only

Organisers: Penny Berry

Fri 27 Jan 2017 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Understanding and targeting human Th17 cells in inflammatory diseases

Dr Liye Chen

Audience: Members of the University only

Organisers: Anne Farmer

Mon 30 Jan 2017 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Structure and function of K2P and PKD ion channels, targets for pain and polycystic kidney disease

Professor Liz Carpenter

Audience: Members of the University only

Organisers: Linda Roberts

Tue 31 Jan 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

How replication impediments impair epigenetic memory

Dr. Julian Sale

Audience: Members of the University only

Organisers: Liz Rose