Consolidated List of all WIMM Seminars

Tue 4 Apr 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Evolution of tissue-specific enhancers across mammals

Dr Duncan Odom

Audience: Members of the University only

Organisers: Liz Rose

Fri 7 Apr 2017 from 14:30 to 15:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

A role for immune cells in sterile injury

Paul Kubes

Audience: Members of the University only

Organisers: Anne Farmer

Wed 19 Apr 2017 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

New cancer immunotherapy strategies: the host is the target

Dr Tobias Janowitz

Audience: Members of the University only

Organisers: Anne Farmer

Mon 24 Apr 2017 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

The A to Zika of Guillain-Barre syndrome

Hugh Willison

Audience: Members of the University only

Organisers: Linda Roberts

Tue 25 Apr 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

MHU Student Presentations

Tomasz Dobrzycki; Akiko Hashimoto; Dominic Owens

Audience: Members of the University only

Organisers: Liz Rose

Tue 25 Apr 2017 from 15:00 to 16:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Novel Technologies For Rapid Generation Of Custom-Designed Animal Models

Dr Matthew Wheeler

Audience: Members of the University only

Organisers: Anne Farmer

Wed 26 Apr 2017 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Assessing the effect of single nucleotide variants on the expression of key human genes

Professor Merlin Crossley

Audience: Members of the University only

Organisers: Liz Rose

Thu 27 Apr 2017 from 12:30 to 13:30

WIMM Occasional Seminars

Genomic instability and disease: opportunities for clinical translation

Dr Gabriel Balmus

Genomic instability (GIN) is a central feature of cancer and ageing that if prevented would lead to disease improvement thus representing an important therapeutic avenue. Our cells are constantly bombarded by external (e.g. ionizing radiations) and internal (e.g. replication stress) factors that... Read more

Genomic instability (GIN) is a central feature of cancer and ageing that if prevented would lead to disease improvement thus representing an important therapeutic avenue. Our cells are constantly bombarded by external (e.g. ionizing radiations) and internal (e.g. replication stress) factors that create DNA lesions (DNA damage). These injuries can range from simple nicks to highly toxic double-strand DNA breaks (DSBs) and are counteracted by the DNA damage response (DDR). The DDR comprises a collection of signal transduction pathways that sense DNA damage and trigger appropriate responses such as DNA repair, temporary or permanent cell cycle arrest (senescence), or cell death (apoptosis or autophagy). Failure to implement these responses results in GIN and initiation of diverse pathologies including cancer and ageing. To explore genetic mechanisms of GIN accumulation, we have performed genetic and drug screens aimed at identifying therapeutic opportunities to alleviate disease. Our results show how different nodes in the disease related pathways can be taken advantage off in order to understand cancer cell resistance/relapse to therapies (e.g. in the context of ATM tumour suppressor gene) or delay ageing (e.g. in the context of Hutchinson-Gilford Progeria Syndrome). Moreover, we use these findings to translate our results to mouse models of disease, pushing closer towards considering these avenues in clinical settings. We emphasize there should be a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner that will aid the diagnosis and treatment of debilitating disease including cancer and ageing.

Audience: Members of the University only

Organisers: Penny Berry

Fri 28 Apr 2017 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Analysis of gonorrhoea in coastal Kenya

Dr Ana Cehovin

Audience: Members of the University only

Organisers: Anne Farmer

Fri 28 Apr 2017 from 11:00 to 11:45

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

CHD7 in CHARGE: the implications of neural crest specific regulation of chromatin remodeller CHD7 in CHARGE syndrome

Günes Taylor

Audience: Members of the University only

Organisers: Liz Rose

VIVA SEMINAR