Consolidated List of all WIMM Seminars

Tue 3 May 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Haematopoietic stem cells in development and disease

Dr Katrin Ottersbach

Audience: Members of the University only

Organisers: Liz Rose

Wed 4 May 2016 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Crosstalk between RNA processing and chromatin remodelling as a modulator of genome integrity

Dr Andres Aguilera

Audience: Members of the University only

Organisers: Liz Rose

Thu 5 May 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Lymphocyte population dynamics and genetic susceptibility to autoimmune disease

Prof Rose Zamoyska

Audience: Members of the University only

Organisers: Anne Farmer

Fri 6 May 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

A vaccine against Salmonella for Africa. Opportunities and Challenges

Prof Cal Maclennan

Audience: Members of the University only

Organisers: Anne Farmer

Mon 9 May 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Control of stem cell fate in mammalian epidermis

Fiona Watt

Audience: Members of the University only

Organisers: Linda Roberts

Wed 11 May 2016 from 01:30 to 02:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Immunotherapy with dendritic cell nanovesicles

Prof Jonathan Sprent

Dongbin Jin and Jonathan Sprent. Garvan Institute of Medical Research, Sydney, Australia Interest in cancer immunotherapy has been bolstered by the recent success of T cell checkpoint (PD-1) blockade with specific antibodies. This approach might be especially effective if combined with methods... Read more

Dongbin Jin and Jonathan Sprent. Garvan Institute of Medical Research, Sydney, Australia Interest in cancer immunotherapy has been bolstered by the recent success of T cell checkpoint (PD-1) blockade with specific antibodies. This approach might be especially effective if combined with methods for enhancing tumor immunogenicity, eg injection of dendritic cells (DC) expressing tumor antigens. Currently, DC therapy is successful in only a small proportion of patients, perhaps reflecting poor homing of injected DC. To overcome this problem, we have generated cell-surface membrane nanovesicles from in vitro-generated bone-marrow-derived mature DC. When loaded with specific peptide, the vesicles are stimulatory for naïve TCR transgenic CD8 T cells in vitro without APC, though only with aggregated vesicles and not with vesicles dispersed into nano-vesicles by sonication. By contrast, after IV injection in vivo, the nanovesicles are much more immunogenic than aggregates and generate strong proliferation and effector function of CD8 cells in both spleen and LN, reflecting widespread distribution of the vesicles and uptake by host APC. Preliminary work has shown that injection of the vesicles can be used to reject established tumours in mice.

Audience: Members of the University only

Organisers: Anne Farmer

Fri 13 May 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Virus restriction and beyond: an update on SAMHD1

Prof Jan Rehwinkel, Jonathan Maelfait, Tamara Davenne

Audience: Members of the University only

Organisers: Anne Farmer

Mon 16 May 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Chemotaxis using self-generated gradients - planning your own route works better than waiting for a signal

Prof Robert Insall

Audience: Members of the University only

Organisers: Linda Roberts

Fri 20 May 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Resolving TYK2 locus genotype-to-phenotype conflict reveals therapeutic optimum for autoimmunity

Dr Calliope A Dendrou

Audience: Members of the University only

Organisers: Anne Farmer

Mon 23 May 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Signalling, cell biology, and rhomboids

Prof Matthew Freeman

Audience: Members of the University only

Organisers: Linda Roberts

Tue 24 May 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Single-cell analysis of Blimp1+ cell types at the maternal-foetal interface

Dr Andrew Nelson

Audience: Members of the University only

Organisers: Liz Rose

Fri 27 May 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

To bnAb or not to bnAb- Are Tregs the answer?

Dr Isabela Pedroza-Pacheco

Audience: Members of the University only

Organisers: Anne Farmer

Fri 27 May 2016 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

HSC developmental diversity

Professor Elaine Dzierzak

Audience: Members of the University only

Organisers: Liz Rose

Tue 31 May 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

MHU Student Presentations

Cristina di Genua; Florian Bonkhofer; Alexander Thomas

Audience: Members of the University only

Organisers: Liz Rose