Consolidated List of all WIMM Seminars

Fri 4 Mar 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

Location, Location, Location: CD8+ T cells and liver-stage malaria

Hill Group, Alex Spencer

Audience: Members of the University only

Organisers: Anne Farmer

Fri 4 Mar 2016 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

"Career paths, work/life balance and equality/diversity"

Professor Angela Vincent, Professor Katja Simon, Professor Paresh Vyas

Audience: Members of the University only

Organisers: Liz Rose

Mon 7 Mar 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Molecular anatomy of the brain by large-scale single cell RNA-seq

Sten Linnarsson

Audience: Members of the University only

Organisers: Linda Roberts

Tue 8 Mar 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

MHU Student Presentations

Anthony Cheong; Jennifer Chambers; Lucas Greder

Audience: Members of the University only

Organisers: Liz Rose

Fri 11 Mar 2016 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Single-cell analysis of haematopoietic stem cell identity and behaviour

Dr David Knapp

Audience: Members of the University only

Organisers: Liz Rose

Mon 14 Mar 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Nutritional control of neural stem cells

Prof Andrea Brand

Audience: Members of the University only

Organisers: Linda Roberts

Mon 14 Mar 2016 from 14:00 to 15:00

WIMM Occasional Seminars

Maintenance of spermatogenic stem cell pool by mitogen competition

Professor Shosei Yoshida

Audience: Members of the University only

Organisers: Liz Rose

Tue 15 Mar 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Chaperones turned oncoproteins: calreticulin mutants pathologically activate TpoR and the JAK-STAT pathway in myeloid cancers

Prof Stefan Constantinescu

Audience: Members of the University only

Organisers: Liz Rose

Wed 16 Mar 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Natural Killer cell receptors and MHC class I ligands in humans and chimpanzees

Professor Peter Parham

Audience: Members of the University only

Organisers: Anne Farmer

Fri 18 Mar 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Update from the Cornall group

Cornall Group

Audience: Members of the University only

Organisers: Anne Farmer

Mon 21 Mar 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

The control of T cell metabolism and differentiation

Prof Doreen Cantrell

Audience: Members of the University only

Organisers: Linda Roberts

Tue 22 Mar 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Cooperative and dynamic organisation of DNA regulatory elements

Dr Guillaume Orsi

Audience: Members of the University only

Organisers: Liz Rose

Thu 24 Mar 2016 from 12:30 to 13:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

How does the Fanconi pathway promote unhooking of DNA interstrand crosslinks?

Dr Puck Knipscheer

DNA interstrand cross-links (ICLs) are highly toxic DNA lesions as they prevent DNA strand separation. ICL repair requires several classes of repair enzymes including translesion DNA polymerases, structure-specific endonucleases, recombinases, and Fanconi anemia (FA) proteins. Mutation in any one... Read more

DNA interstrand cross-links (ICLs) are highly toxic DNA lesions as they prevent DNA strand separation. ICL repair requires several classes of repair enzymes including translesion DNA polymerases, structure-specific endonucleases, recombinases, and Fanconi anemia (FA) proteins. Mutation in any one of the 16 currently known FA genes leads to the cancer predisposition disorder Fanconi anemia. However, it is still largely unclear how the FA proteins and the other repair factors collaborate to repair ICLs. We study the molecular mechanism of ICL repair using a Xenopus egg extract-based system that recapitulates replication-dependent ICL repair in vitro. Previously we have shown that activation of the FA pathway by ubiquitylation of the FANCI-FANCD2 (ID) complex is important for a specific step in ICL repair, namely the incisions that unhook the lesion from one of the DNA strands. We next demonstrated that binding of this activated ID complex to the crosslink promotes the recruitment of the incision-complex, composed of the adapter protein SLX4 and the structure specific endonuclease XPF-ERCC1. Both XPF and SLX4 have recently been identified as FA genes highlighting their importance in ICL repair. Although ICL unhooking appears to be a major function of the FA pathway the biochemical details of this process are still unclear. I will present our latest findings regarding the role of XPF-ERCC1 and SLX4 in ICL repair.

Audience: Members of the University only

Organisers: Penny Berry