Consolidated List of all WIMM Seminars

Thu 1 Dec 2016 from 11:00 to 11:45

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

New approaches to the investigation of the interactions between enhancers and promoters during haemopoiesis

Dr James Davies

Audience: Members of the University only

Organisers: Liz Rose

VIVA SEMINAR

Thu 1 Dec 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Targeting leukemia by lipid specific T cells

Dr Giulia Casorati

Audience: Members of the University only

Organisers: Anne Farmer

Fri 2 Dec 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Plasma membrane lipids: a passive or active environment?

Prof Christian Eggeling

Audience: Members of the University only

Organisers: Anne Farmer

Fri 2 Dec 2016 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Long-distance interactions in gene expression control: function and regulation by the 3D genome's architecture

Dr Francois Spitz

Audience: Members of the University only

Organisers: Liz Rose

Mon 5 Dec 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

3D Chromatin Folding Determines Pathogenicity of Structural Variations

Stefan Mundlos

Audience: Members of the University only

Organisers: Linda Roberts

Tue 6 Dec 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Exploring the role of SCF at the onset of haematopoiesis

Emanuele Azzoni

Audience: Members of the University only

Organisers: Liz Rose

POSTPONED TO THE NEW YEAR

Tue 6 Dec 2016 from 15:00 to 16:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

PD-1 cancer immunotherapy

Professor Gordon Freeman

Audience: Members of the University only

Organisers: Anne Farmer

Wed 7 Dec 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Antibody Responses in Dengue and Zika Infection

Prof Gavin Screaton

Audience: Members of the University only

Organisers: Anne Farmer

Thu 8 Dec 2016 from 14:00 to 15:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection

Professor Petr Cejka

To repair a DNA double-strand break (DSB) by homologous recombination (HR), the 5'-terminated strand of the DSB must be resected. The human MRE11-RAD50-NBS1 (MRN) and CtIP proteins were implicated in the initiation of DNA end resection, but the underlying mechanism remained undefined. Here we show... Read more

To repair a DNA double-strand break (DSB) by homologous recombination (HR), the 5'-terminated strand of the DSB must be resected. The human MRE11-RAD50-NBS1 (MRN) and CtIP proteins were implicated in the initiation of DNA end resection, but the underlying mechanism remained undefined. Here we show that CtIP is a co-factor of the MRE11 endonuclease activity within the MRN complex. This function is absolutely dependent on CtIP phosphorylation that includes the key cyclin-dependent kinase target motif at Thr-847. Unlike in yeast where the Xrs2/NBS1 subunit is dispensable in vitro, NBS1 is absolutely required in the human system. The MRE11 endonuclease in conjunction with RAD50, NBS1 and phosphorylated CtIP preferentially cleaves 5'-terminated DNA strands near DSBs. Our results define the initial step of HR that is particularly relevant for the processing of DSBs bearing protein blocks or secondary DNA structures.

Audience: Members of the University only

Organisers: Penny Berry

Wed 14 Dec 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

IFITM3 Regulation of Viral Pathogenesis

Prof Ian Humphreys

Audience: Members of the University only

Organisers: Anne Farmer

Tue 20 Dec 2016 from 11:00 to 12:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Lineage commitment and chromatin dynamics

Professor Frank Grosveld

Audience: Members of the University only

Organisers: Liz Rose

Tue 20 Dec 2016 from 13:00 to 13:45

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

The role of elements binding CTCF and Cohesin in directing tissue-specific enhancer activity

Lars Hanssen

Audience: Members of the University only

Organisers: Liz Rose

VIVA SEMINAR