Consolidated List of all WIMM Seminars

Thu 19 Oct 2017 from 12:30 to 13:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

IGF2BP1 promotes the immune escape in advanced stage ovarian cancer

Dr Nadine Bley

The mRNA binding protein IGF2BP1 (IGF2 mRNA binding protein) is an oncofetal protein de novo synthesized in various aggressive solid cancers. In the cytoplasm, the protein controls the localization, translation and/or turnover of target mRNAs and thereby modulates cell proliferation, migration and... Read more

The mRNA binding protein IGF2BP1 (IGF2 mRNA binding protein) is an oncofetal protein de novo synthesized in various aggressive solid cancers. In the cytoplasm, the protein controls the localization, translation and/or turnover of target mRNAs and thereby modulates cell proliferation, migration and invasion during development and cancer. In epithelial ovarian carcinoma (EOC) high levels of IGF2BP1 expression are significantly correlated with poorer prognosis and associated with the mesenchymal subtype of EOC, characterized by a reduced immune signature. Aiming to characterize the role of IGF2BP1 in EOC we used a combination of deep sequencing and quantitative proteomics. As expected we identified the protein as an essential regulator of cell migration and invasion. More strikingly, an IGF2BP1-dependent modulation of components of the MHC class I antigen processing and presentation machinery (APM) was found in EOC-derived cells, which is in line with the frequent deficiencies in these molecules in EOC lesions. IGF2BP1 repressed the expression of genes essential for MHC class I antigen processing machinery leading to an impaired MHC class I surface antigen expression. Additionally, IGF2BP1 promoted CD274/PD-L1 expression which itself represses the proliferation of activated T-cells. In summary, our data suggest that IGF2BP1 promotes the immune escape of invasive cancer cells in advanced stage ovarian cancer.

Audience: Members of the University only

Organisers: Penny Berry

Fri 20 Oct 2017 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

How to PERK up your iNKT cells: A novel mechanism of iNKT cell activation via ER-stressed APCs

Melissa Bedard (Cerundolo Group)

Audience: Members of the University only

Organisers: Anne Farmer

Fri 20 Oct 2017 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

“CRISPR-Cas Gene Editing: Defining Genome-wide Activity for Therapeutics”

Shengdar Tsai

Audience: Members of the University only

Organisers: Liz Rose

Mon 23 Oct 2017 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Does evasion of innate sensing explain pandemic potential of primate lentiviruses in humans

Professor Greg Towers

Audience: Members of the University only

Organisers: Linda Roberts

Tue 24 Oct 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

The emergence of erythropoiesis from the early haematopoietic hierarchy: a single cell-RNA-seq approach

Assoc Prof Merav Socolovsky

Audience: Members of the University only

Organisers: Liz Rose

Fri 27 Oct 2017 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Activation of human innate-like T cells by adenovirus vectors

Dr Nicholas Provine

Audience: Members of the University only

Organisers: Anne Farmer

Fri 27 Oct 2017 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

How LAB282 accelerates Oxford drug discovery

Thomas Hank

Audience: Members of the University only

Organisers: Sarah Butler

Mon 30 Oct 2017 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

The first ten hours in the life of the frog

Sir Jim Smith

Audience: Public

Organisers: Linda Roberts

Tue 31 Oct 2017 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Exploring the mechanisms of haematopoietic lineage progression at the single-cell level

Professor Ana Cvejic

Audience: Members of the University only

Organisers: Liz Rose