The symptoms of anaemia are tiredness, shortness of breath and being pale.
The anaemia in CDA is very variable.
- In some patients, it is very mild and does not cause them significant symptoms.
- In other patients, it is moderate and patients may require blood transfusions if they are unwell with an infection.
- In the remainder of patients, it is severe and the patients are dependent on transfusions regularly for their whole life.
A buildup of iron is one of the complications of CDA. This can result from blood transfusions, or can simply be a feature of CDA without transfusions. in those cases, patients absorb more iron than they should from their diet. Too much iron can be very harmful to the body as humans don’t have any way of getting rid of excess iron. This means iron will accumulate in the liver, the heart, the pancreas and other organs. To prevent the serious complications that would follow, patients with iron overload are treated with medications called iron chelators. These bind the excess iron and get rid of it.